Unique stem cell lines identifier |
1. SCVIi049-A |
|
2. SCVIi050-A |
Alternative name(s) of stem cell lines |
1. SCVIi049-A / SCVI104 |
|
2. SCVIi050-A / SCVI2486 |
Institution |
Stanford Cardiovascular Institute, Stanford, CA, US |
Contact information of distributor |
Joseph C. Wu, joewu@stanford.edu
|
Type of cell lines |
iPSC |
Origin |
Human |
Additional origin info required for human ESC or iPSC |
Age: 44 (SCVIi049-A) and 30 (SCVIi050-A) |
|
Sex: male |
|
Ethnicity if known: Not Hispanic or Latino |
Cell Source |
Fibroblast (SCVIi049-A), PBMC (SCVIi050-A) |
Clonality |
Clonal |
Method of reprogramming |
Nonintegrating Sendai virus expression of human OCT4, SOX2, KLF4, and c-MYC |
Genetic Modification |
Yes |
Type of Genetic Modification |
Spontaneous mutation |
Evidence of the reprogramming transgene loss (including genomic copy if applicable) |
RT-qPCR |
Associated disease |
Dilated cardiomyopathy (DCM) |
Gene/locus |
PLN (6q22.31) |
|
SCVIi049-A: heterozygous PLN (c.25C > T) |
|
SCVIi050-A: heterozygous PLN (c.40_42delAGA) |
Date archived/stock date |
SCVIi049-A: 09/10/2019 |
|
SCVIi050-A: 12/03/2021 |
Cell line repository/bank |
https://hpscreg.eu/cell-line/SCVIi049-A
|
|
https://hpscreg.eu/cell-line/SCVIi050-A
|
Ethical approval |
The generation of the lines was approved by the Administrative Panel of Human Subjects Research (IRB) under IRB #29904 “Derivation of Human Induced Pluripotent Stem Cells” |