TABLE 1.
Comparison of proportions of taxanes absorbed into NCI/ADR-RES ovarian cancer cells after 120 min incubation with 10 µM PTX, SB-T-1216, SB-T-121605, and SB-T-121606 taxanes and their HPLC detection. Significant results are marked as: *** (p ≤ 0.001).
| Taxane | Percentage of absorbed drugs in NCI/ADR-RES cells a | Significance of differences between SB-T and PTX absorption |
|---|---|---|
| Conventional taxane | ||
| PTX | 0.6 ± 0.3 | --- |
| Second-generation taxane | ||
| SB-T-1216 | 3.6 ± 0.3 | 3.52E-04*** |
| Third-generation taxane | ||
| SB-T-121605 | 9.3 ± 0.8 | 9.32E-04*** |
| SB-T-121606 | 6.2 ± 0.5 | 1.18E-04*** |
a
The percentage of taxanes absorbed by the cells (0.5 × 106/ml/well) after 120 min incubation and HPLC, detection is expressed as mean (%) ± S.D., of three separate experimental values (n = 3).