TABLE 2.
Two-sample MR analyses of associations between CD40/CD40L and aortic diseases.
| Exposure | Outcome | Method | nSNP | OR | 95% CI | p-Value |
|---|---|---|---|---|---|---|
| CD40 | AD | IVW | 3 | 0.777 | 0.618–0.978 | 0.031 |
| CD40 | AA | IVW | 3 | 0.905 | 0.837–0.978 | 0.012 |
| CD40 | TAA | IVW | 3 | 0.906 | 0.837–0.981 | 0.015 |
| CD40 | AAA | IVW | 3 | 0.851 | 0.753–0.962 | 0.010 |
| CD40-L | AD | Wald ratio | 1 | 2.779 | 0.508–15.205 | 0.239 |
| CD40-L | AA | Wald ratio | 1 | 1.091 | 0.608–1.957 | 0.770 |
| CD40-L | TAA | Wald ratio | 1 | 1.116 | 0.616–2.020 | 0.718 |
| CD40-L | AAA | Wald ratio | 1 | 1.029 | 0.410–2.582 | 0.952 |
MR, mendelian randomization; SNPs, single nucleotide polymorphisms; AD, aortic dissection; AA, aortic aneurysm; TAA, thoracic aortic aneurysm; AAA, abdominal aortic aneurysm; IVW, inverse variance weighted (fixed effects); OR, odds ratio; CI, confidence interval.