FIGURE 4.

CPL500036 induces catalepsy at a dose of 0.6 mg/kg. The cataleptic response was assessed 60 min–240 min after administration of CPL500036 (0.15 mg/kg, 0.3 mg/kg, 0.6 mg/kg, and 2 mg/kg, p.o.) or haloperidol (1 mg/kg, i.p.). Catalepsy in the time course (A) and as the area under the curve (B) is presented as the mean and SEM. For the time-course, two-way mixed-design ANOVA demonstrated significant effects of an interaction between treatment and time: F (30, 300) = 3.19; p < 0.05; the post hoc test revealed differences between treatment and vehicle (*p < 0.05) and between treatment and haloperidol (#p < 0.05). One-way ANOVA on AUC data (lB) showed differences among groups: F (5,50) = 80.53; p < 0.05; the post hoc test demonstrated differences between treatment and vehicle *p < 0.05 and treatment and haloperidol effects #p < 0.05. N = 8–12/group.