TABLE 2.
Pharmacokinetic parameters after oral gavage of CPL500036 in a dose of 3 mg/kg in rats and 1.5 mg/kg in dogs’. Data are the mean ± SD.
| Rat (n = 5/timepoint) | Dog (n = 4) | ||
|---|---|---|---|
| Parameter | Plasma | Brain | Plasma |
| Cmax (ng/ml) | 237.8 ± 98.1 | 94.3 ± 28.5 | 98.3 ± 55.4 |
| Tmax (h) | 5.8 ± 1.6 | 6.8 ± 3.3 | 1.3 ± 0.5 |
| AUC(0–24h) (ng*h/ml) | 1,618.0 ± 298.3 | 843.6 ± 202.2 | 199.4 ± 105.5 |
| t1/2 (h) | 6.4 ± 6.2 | – | 2.1 ± 1.7 |
| B/P | – | 0.49 ± 0.06 | – |
Abbreviations: Cmax, maximum concentration; Tmax, time to Cmax; AUC0–t, area under the concentration–time curve; t1/2 - half-life of elimination, B/P, brain to plasma ratio.