TABLE 3.
Population pharmacokinetic parameters of MM and theory-based base models.
| Parameters | Estimate | RSE (%) | 95%CI | BSV (%) | RUV |
|---|---|---|---|---|---|
| Theory-based model | |||||
| CLPl/F (L h−1) | 456 | 3.6 | 424–488 | 42.2 | 14.3% |
| VPl/F (L) | 10700 | 10.2 | 8,564–12836 | 64.4 | |
| Ka (h−1) | 4.48 fixed | — | — | — | |
| MM model | |||||
| Vm (mg day−1) | 6.1 | 6 | 5.385–6.815 | — | 0.48 mg day−1 |
| Km (ng ml−1) | 6.19 | 13.6 | 4.542–7.838 | 74.8 | 29% |
CLPl/F, the apparent plasma clearance; VPl/F, the apparent plasma volume of distribution; Ka, absorption rate constant; Vm, the maximum dose rate (daily dose) at the steady state; Km, the Michaelis constant which denotes the steady-state trough concentration at half-maximal dose rate; BSV, between subject variability; RUV, unexplained residual error; CI, confidence interval; RSE, relative standard error; MM, Michaelis-Menten.