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. 2022 Nov 21;13:129. doi: 10.1007/s12672-022-00593-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Overall Meta-analytical Comparison of US-SRT and XRT/SRT Outcomes in the Treatment of Basal Cell Cancer (BCC), Squamous Cell Cancer (SCC) and Squamous Cell Cancer in Situ (SCCIS). All Lesions Contrasts: Yu US-SRT v. XRT/SRT Studies Combined, Q [1] = 51.5, p < 0.0001. Moloney US-SRT vs. XRT/SRT Studies Combined, Q [1] = 79.3, p < 0.001. The displayed overall effect size for US-SRT contains correlated outcomes (i.e., shared patients in part across investigators). The common effect size for XRT/SRT outcomes contains independent outcomes with the rare exception of a few patients who present with more than one carcinoma type. Therefore, separate analyses are presented for the US-SRT investigators, Yu and Moloney, to maintain the assumption of within-analysis independence