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. 2022 Nov 9;10:1036380. doi: 10.3389/fchem.2022.1036380

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Copyright © 2022 Liu, Zhao, Liu, Huang and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BYHWD attenuated the body weight increase and fat accumulation induced by HFD in diabetic ZDF rats: (A) experimental period and treatments’ arrangement; (B) average weight change during treatments; (C) comparison of weight gain during the experimental period among four different groups; (D) comparison on the accumulation of mesenteric fat, epididymis fat, and perirenal fat among four different groups; (E) comparison of the ratio of total fat vs. body weight among four different groups. Data are shown as means ± S.D (n = 6–8). Statistical analysis was performed by using one-way ANOVA, followed by Tukey’s multiple comparisons test for the false discovery rate. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 were set to compare the mean of each group with the mean of every other group.