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. 2022 Nov 9;10:1036380. doi: 10.3389/fchem.2022.1036380

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Copyright © 2022 Liu, Zhao, Liu, Huang and Xia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BYHWD maintained the normal structure of the islet and adjusted the abnormal glucose metabolism induced by HFD in ZDF rats: (A) representative HE images of the rat pancreas from different groups; (B) the comparison of the blood glucose, serum insulin, and the HOMA-IR index among four groups at the end of the treatments; (C) the comparison of the results of the OGTT among the four groups during the experimental period. Data are shown as means ± S.D (n = 6–8). Statistical analysis was performed using one-way ANOVA, followed by Tukey’s multiple comparisons test for the false discovery rate. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 were set to compare the mean of each group with the mean of every other group.