TABLE 1.
Significantly different qualitative lipid metabolites in the liver samples from ZDF rats after BYHWD treatment.
| Lipid metabolite | VIPa | Fold-changeb | log2(FC_DM/BYHW)c | p-valued |
|---|---|---|---|---|
| Increased | ||||
| TG (37:6) | 1.22 | 0.21 | −2.24 | 0.031 |
| TG (18:4_18:2_18:3) | 2.41 | 0.26 | −1.94 | 0.003 |
| PC (36:1e) | 1.12 | 0.59 | −0.77 | 0.005 |
| PC (36:2e) | 2.82 | 0.64 | −0.64 | 0.018 |
| PE (38:4) | 1.12 | 0.64 | −0.64 | 0.024 |
| PE (17:1_20:4) | 1.37 | 0.73 | −0.46 | 0.041 |
| PC (41:3e) | 3.33 | 0.73 | −0.45 | 0.018 |
| TG (18:0_18:0_20:4) | 1.08 | 0.74 | −0.43 | 0.024 |
| ChE (20:4) | 1.58 | 0.75 | −0.42 | 0.031 |
| SM (d18:1_24:0) | 2.29 | 0.76 | −0.39 | 0.018 |
| PC (35:3) | 5.01 | 0.77 | −0.37 | 0.018 |
| MGDG (38:1e) | 1.23 | 0.80 | −0.31 | 0.004 |
| BisMePA (18:2_18:2) | 4.74 | 0.82 | −0.29 | 0.014 |
| MePC (30:0) | 4.74 | 0.82 | −0.29 | 0.014 |
| SM (d44:4) | 1.69 | 0.84 | −0.25 | 0.031 |
| PC (33:3) | 4.18 | 0.85 | −0.23 | 0.014 |
| Hex2Cer (d14:1_20:4) | 1.14 | 0.86 | −0.22 | 0.041 |
| TG (15:0_18:2_22:5) | 1.30 | 0.88 | −0.18 | 0.041 |
| MePC (34:4) | 7.54 | 0.94 | −0.09 | 0.041 |
| Decreased | ||||
| TG (20:4_22:6_22:6) | 2.08 | 2.16 | 1.11 | 0.031 |
| TG (12:1e_6:0_18:0) | 1.30 | 1.95 | 0.97 | 0.024 |
| DG (34:2) | 1.70 | 1.85 | 0.89 | 0.041 |
| PC (17:1_16:0) | 1.30 | 1.85 | 0.89 | 0.018 |
| TG (17:0_6:0_18:2) | 1.20 | 1.81 | 0.86 | 0.041 |
| TG (20:2_20:2_20:5) | 1.51 | 1.53 | 0.61 | 0.004 |
| DG (22:5_22:5) | 1.03 | 1.51 | 0.60 | 0.031 |
| TG (12:1e_6:0_22:5) | 1.20 | 1.52 | 0.60 | 0.014 |
| DG (18:2_22:6) | 2.86 | 1.47 | 0.56 | 0.024 |
| DG (22:6_22:6) | 4.64 | 1.39 | 0.48 | 0.005 |
| TG (22:5_17:1_18:2) | 1.45 | 1.29 | 0.37 | 0.041 |
| CL (78:11) | 3.50 | 1.27 | 0.35 | 0.014 |
| PC (30:0) | 1.98 | 1.26 | 0.33 | 0.024 |
| SPH (d18:1) | 1.19 | 1.22 | 0.29 | 0.031 |
| LBPA (16:0_18:1) | 1.78 | 1.18 | 0.24 | 0.041 |
| PC (40:7e) | 1.08 | 1.18 | 0.24 | 0.041 |
| PC (17:0_22:6) | 1.02 | 1.17 | 0.22 | 0.007 |
| PC (18:2_20:4) | 2.03 | 1.15 | 0.21 | 0.018 |
| PC (39:6) | 3.86 | 1.16 | 0.21 | 0.041 |
| PE (16:1e_22:6) | 1.10 | 1.16 | 0.21 | 0.024 |
| BisMePA (40:9e) | 1.20 | 1.13 | 0.18 | 0.014 |
| TG (18:0_22:6_22:6) | 1.32 | 1.13 | 0.18 | 0.041 |
| PE (18:1p_22:6) | 1.13 | 1.12 | 0.16 | 0.014 |
| PG (30:0_16:0) | 4.75 | 1.11 | 0.16 | 0.031 |
a,d Significantly different lipid metabolites with VIP values > 1.0 and p < 0.05 were selected. b,cFc indicates the fold-change calculated as the relative altered ratio of significantly different lipid metabolites between the BYHWD and DM groups.