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. 2022 Nov 9;12:1059253. doi: 10.3389/fonc.2022.1059253

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Copyright © 2022 Wang, Zhang, Du, Wu, Zhou, Chen and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The role of CAFs in affecting lung cancer biological pathways and immunotherapy response. (A) The GSEA analysis between high- and low-CAFs groups based on the Hallmark gene set; (B) The GSEA analysis between high- and low-CAFs groups based on the GO gene set; (C) Correlation analysis between TIDE score and CAFs score; (D) CAFs level in immunotherapy responders and non-responders ***P < 0.001; (E) Percentage of immunotherapy responders in patients with high and low CAFs infiltration, *P < 0.05.