Table 2.

Effects of CARD9-deficient mice on microbial infection.

Microbe	Pathogens	Receptors	Effects	Organ involvement	References
Fungi	Pneumocystis	Dectin-1/Mincle	Impaired proinflammatory response/cell differentiation	Lung	Kottom et al., 2020b
	Mucor irregularis	CLRs	Impaired cytokine and chemokine production	CNS	Sun et al., 2021
	Rhizopus arrhizus	PRRs	Impaired local cytokine production/Th cells response	Inguinal lymph nodes	Sun et al., 2019
	Candida albicans	CLRs	Impaired cytokine and chemokine production	CNS	Drummond et al., 2019
Bacteria	Streptococcus pneumoniae	Dectin-2	Decreased neutrophil accumulation	Lung	Ishizuka et al., 2020
Viruses	LACV	Dectin-1/Dectin-2/Mincle	Impaired cytokine production	Dendritic cells	Monteiro et al., 2019
	TMEV	CLRs	Increased loss of neuronal protein	Brain	Pavasutthipaisit et al., 2021
	CVB3	CLRs	Impaired cytokine production	Myocardium	Sun et al., 2020
Parasites	Plasmodium berghei	TLRs	Elevated proinflammatory response	Brain	Hafalla et al., 2012

LACV, La Crosse Virus; TMEV, Theiler's murine encephalomyelitis virus; CVB3, Coxsackievirus B3; CLRs, C-type lectin receptors; PRRs, pattern recognition receptors; TLRs, toll-like receptors; CNS, central nervous system.