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. 2022 Nov 9;13:983621. doi: 10.3389/fimmu.2022.983621

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Copyright © 2022 Babayeva, Tabynov, Nurpeisov, Fomin, Renukaradhya, Petrovsky and Tabynov

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Art v 1 stimulated cytokine profiles in splenocytes of BALB/c mice after pre- and co-seasonal ASIT with different vaccine formulations. Cytokine data are presented as difference (delta) between samples with and without stimulation with Art v 1 protein and expressed in pg/mL. In addition, ratios between the IFN-γ and IL-4 are presented to assess Th1/Th2 balance. Differences between groups were assessed using Tukey’s multiple comparisons test. NS - not significant. A P<0.05 value was considered a significant difference. *P <0.05, **P <0.01, ***P <0.001, and ****P <0.0001.