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. 2022 Nov 9;12:1028267. doi: 10.3389/fcimb.2022.1028267

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Copyright © 2022 Wu, Xu, Wang, Chen, Lv, Zheng, Yan, Jiang, Shen, Wang, Wang, Xia, Han and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pectin attenuates C. difficile-induced dysregulation of the intestinal metabolome. (A) Three-dimensional PLS-DA score plots of metabolome profiles for the four groups. (B, C) OPLS-DA plots between groups. (D) Heatmap for the selected metabolites in the CCDI and PCDI groups. (E) Pathway of the differentially abundant metabolites between the CCDI and PCDI groups. (F) SCFA levels in the cecal contents of mice. *, P<0.05; **, P<0.01; ***, P<0.001; ns, differences are not significant. PLS-DA, Partial least squares discrimination analysis; OPLS-DA, orthogonal PLS-DA. The red color showed valuable differential metabolites.