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. 2022 Nov 9;12:1041682. doi: 10.3389/fcimb.2022.1041682

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Copyright © 2022 Liu, Ji, Cheng, Chen, Geng, Huang, Zhang, He and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA regulates RIG-I signaling pathway in tumor cells. LncRNAs competitively bind to miRNA and indirectly inhibit miRNA-targeted mRNA expression, thereby inhibiting the activation of the RIG-I downstream signaling pathway. RIG-I acts as a direct target of miR-545. LncRNA FTX competitively binds to miR-545, thereby inhibiting mRNA expression in HCC cells. LncRNA AFAP1-AS1 affects mRNA, activating the positive-feedback regulation loop of IFN signaling and promoting migration and invation of NSCLC.