TABLE 4.

MR estimates from different methods assessing the causal effect of NAFLD on lean body mass.

Exposure	Outcome	Method	Beta	95%CI	P
NAFLD (4 SNPs, F statistic = 74.299, MR power = 0.43)	Whole body lean mass	IVW	–0.068	−0.179 to 0.043	0.229
		Weighted median	–0.040	−0.150 to 0.071	0.484
		MR-Egger	0.180	-0.098 to 0.457	0.333
		Cochran’s Q = 0.499 (P = 0.779); MR-Egger intercept = −0.110 (P = 0.203)
		MR-PRESSO	–0.068	−0.179 to 0.043	0.315
		Weighted mode	–0.019	−0.142 to 0.104	0.780
NAFLD (4 SNPs, F statistic = 74.299, MR power = 0.08)	Appendicular lean mass	IVW	–0.020	−0.092 to 0.051	0.574
		Weighted median	–0.013	−0.082 to 0.056	0.709
		MR-Egger	0.124	-0.046 to 0.294	0.290
		Cochran’s Q = 1.230 (P = 0.541); MR-Egger intercept = −0.063 (P = 0.218)
		MR-PRESSO	–0.020	−0.092 to 0.051	0.613
		Weighted mode	0.002	−0.076 to 0.081	0.955

OR, odds ratio; CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; SNP, single nucleotide polymorphism; IVW, inverse variance weighted; PRESSO, pleiotropy residual sum and outlier.