TABLE 2.
Diverse disease hallmarks are associated with AD genes.
| General criteria | Health conditions/Loci | # Matched gene hits (total genes)* |
| Neurological | Alzheimer’s disease, Familial, 1 | 112 (836) |
| Neurological | Nervous system disease | 91 (897) |
| Diabetes | Type 2 diabetes mellitus | 84 (555) |
| Cardiovascular | Myocardial infarction | 68 (302) |
| QTL* | Body mass index quantitative trait locus 11 | 76 (819) |
| Cancer | Breast cancer | 73 (1,447) |
| Cardiovascular | Heart disease | 61 (366) |
| Cardiovascular | Hypertension, essential | 59 (457) |
| Cancer | Colorectal cancer | 70 (1,492) |
| Neurological | Amyotrophic lateral sclerosis 1 | 55 (579) |
| Cardiovascular | Cardiovascular system disease | 51 (192) |
| Neurological | Parkinson’s disease, late-onset | 52 (387) |
| Other | Lipoprotein quantitative trait locus | 49 (248) |
| Cardiovascular | Vascular disease | 44 (149) |
| Neurological | Schizophrenia | 48 (464) |
| Neurological | Peripheral nervous system disease | 46 (369) |
| Cancer | Prostate cancer | 56 (1,121) |
| Other | Osteoporosis | 44 (308) |
| Cancer | Lung cancer | 50 (1,218) |
| Other | Cystic fibrosis | 40 (333) |
The top 20 diseases in the high tier (p-value equal or less than 0.0001) are listed. The AD gene sets in Table 1 are used to identify diseases using all 356 AD genes (Vahdati Nia et al., 2017) and the web-based search using GeneAnalytics (Accessed on June 28, 2022).
*The number of AD gene hits (total genes classified in each group of the health conditions/Loci).