Figure 1.

Comprehensive schematic of the role oxidative stress plays in cardiovascular disease. The multiplicity of risk factors for cardiovascular disease that drive oxidative stress which in turn results in a well-defined cascade of events that drive the development of atheroma in the vessel is presented. These cellular events lead to a decrease in lifespan and an increase in dementia and cancer risk. The linkage between lipids and inflammation is a critical consideration in the management of cardiovascular disease. Reduction in critical risk factors and the judicious use of medications (blue) can reduce levels of oxidative stress and in turn halt the progression of events leading to the development of atheroma.