TABLE 2.
Comparisons of fractional anisotropy (FA) values.
Tracts | NC (n = 20) | a-MCI (n = 33) | CSVD-MCI (n = 25) | F-value | P-value |
ATR.L | 0.322 ± 0.042 | 0.317 ± 0.035 | 0.286 ± 0.033 | 5.400 | 0.007bc |
ATR.R | 0.321 ± 0.049 | 0.304 ± 0.036 | 0.271 ± 0.033 | 7.008 | 0.002bc |
CST.L | 0.486 ± 0.047 | 0.482 ± 0.032 | 0.460 ± 0.037 | 2.089 | 0.131 |
CST.R | 0.489 ± 0.043 | 0.487 ± 0.033 | 0.464 ± 0.034 | 2.725 | 0.072 |
CgC.L | 0.409 ± 0.048 | 0.352 ± 0.049 | 0.355 ± 0.053 | 6.746 | 0.002ab |
CgC.R | 0.385 ± 0.075 | 0.333 ± 0.040 | 0.357 ± 0.058 | 4.053 | 0.021a |
CgH.L | 0.325 ± 0.043 | 0.270 ± 0.044 | 0.280 ± 0.046 | 9.269 | <0.001ab |
CgH.R | 0.322 ± 0.071 | 0.259 ± 0.030 | 0.266 ± 0.061 | 7.451 | 0.001ab |
Fma | 0.495 ± 0.034 | 0.462 ± 0.048 | 0.434 ± 0.045 | 8.352 | 0.001ab |
Fmi | 0.387 ± 0.041 | 0.359 ± 0.034 | 0.331 ± 0.029 | 13.841 | <0.001abc |
IFO.L | 0.386 ± 0.047 | 0.353 ± 0.033 | 0.344 ± 0.026 | 6.765 | 0.002ab |
IFO.R | 0.383 ± 0.066 | 0.364 ± 0.036 | 0.337 ± 0.029 | 4.288 | 0.017b |
ILF.L | 0.402 ± 0.065 | 0.363 ± 0.032 | 0.339 ± 0.024 | 9.834 | <0.001ab |
ILF.R | 0.405 ± 0.063 | 0.367 ± 0.032 | 0.336 ± 0.022 | 12.711 | <0.001abc |
SLF.L | 0.336 ± 0.044 | 0.307 ± 0.032 | 0.297 ± 0.025 | 5.325 | 0.007ab |
SLF.R | 0.337 ± 0.039 | 0.307 ± 0.033 | 0.301 ± 0.033 | 5.625 | 0.005ab |
UF.L | 0.345 ± 0.041 | 0.308 ± 0.045 | 0.317 ± 0.031 | 5.890 | 0.004ab |
UF.R | 0.346 ± 0.044 | 0.310 ± 0.048 | 0.314 ± 0.035 | 4.929 | 0.010ab |
tSLF.L | 0.400 ± 0.055 | 0.398 ± 0.034 | 0.371 ± 0.049 | 2.460 | 0.093 |
tSLF.R | 0.430 ± 0.038 | 0.402 ± 0.065 | 0.383 ± 0.049 | 2.079 | 0.132 |
NC, normal controls; a-MCI, amnestic mild cognitive impairment; CSVD-MCI, mild cognitive impairment resulting from cerebral small vessel disease; ATR, anterior thalamic radiation; CST, corticospinal tract; CgC, cingulum (cingulate gyrus); CgH, cingulum (hippocampus); Fma, forceps major; Fmi, forceps minor; IFO, inferior fronto-occipital fasciculus; ILF, inferior longitudinal fasciculus; SLF, superior longitudinal fasciculus; UF, uncinate fasciculus; tSLF, superior longitudinal fasciculus-temporal part; L, left; R, right; FA, fractional anisotropy. FA values are mean ± SD.
Post-hoc paired comparisons showed significant group differences: aP < 0.05 between NC and a-MCI; bP < 0.05 between NC and CSVD-MCI; cP < 0.05 between a-MCI and CSVD-MCI.