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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Biochemistry. 2022 Jun 24;61(13):1260–1272. doi: 10.1021/acs.biochem.2c00157

Figure 1.

Figure 1.

Acetylated histone-binding site, “WPF” shelf tryptophan (red), and a basic interaction site (blue) for (A) BRDT–BD1 (W50, K37, K41, and K45) and (B) BRD4–BD1 (W81, R68, K72, and K76). (C) Sequence similarity in each bromodomain of BRDT (left) and BRD4 (right) relative to BRD4–BD1. Percent similarities were relative to BRD4–BD1 calculated by the PDB sequence and structure alignment (PDB ID: 7L73 for BRDT–BD1 and 3UVW for BRD4–BD1).