Figure 6.

The PAH-induced changes in PA and RV for a period of 1000 days: (a) RV remodelling. Thickness increases to mimic concentric hypertrophy, undeformed radius and luminal volume increase after 250 days to mimic the eccentric hypertrophy of RV. (b) PA remodelling. Up to day 250, associated with increase in PVR and from day 450 due to increase in TBV, the PA mass thus thickness increases. PA stiffness, however, decreases due to drop in pressure associated with reduction in RV contractility after day 250. (c) RV fibre stress and (d) PA constituents stress. Stress and stretch for both RV and PA increase due to PVR elevation but significantly reduces due to adaptation to minimize the deviation from the reference stress and stretch.