Table 2.
15 TWAS-identified genes associated with hypertension in four tissues.
| Gene | Chromosome | BEST.GWAS.ID |
PFDR value |
Associated with autoimmunitya | |||
|---|---|---|---|---|---|---|---|
| Left Ventricle | Aorta | Whole Blood | Peripheral Blood | ||||
| GFPT1 | 2 | rs4852868 | 6.38E-03 | 1.88E-03 | 2.95E-02 | 1.04E-02 | NR |
| RBM6 | 3 | rs6785549 | 1.32E-03 | 2.23E-03 | 6.30E-03 | 3.00E-03 | Yes |
| ZNF589 | 3 | rs6800730 | 1.56E-02 | 1.07E-04 | 3.32E-04 | 9.65E-05 | NR |
| HLA-DRB5 | 6 | rs3130342 | 4.88E-03 | 1.25E-02 | 4.44E-04 | 6.52E-05 | Yes |
| UHRF1BP1 | 6 | rs205262 | 5.48E-05 | 5.54E-05 | 3.77E-05 | 5.88E-06 | Yes |
| NEIL2 | 8 | rs11998678 | 4.30E-04 | 1.06E-03 | 2.69E-02 | 6.24E-05 | NR |
| NSUN6 | 10 | rs11014171 | 1.19E-02 | 6.69E-03 | 3.54E-02 | 8.86E-03 | NR |
| SFXN4 | 10 | rs915272 | 2.53E-02 | 2.15E-02 | 1.73E-02 | 2.56E-02 | NR |
| TNNT3 | 11 | rs4980379 | 2.18E-09 | 2.95E-06 | 2.21E-12 | 2.40E-07 | NR |
| LYZ | 12 | rs618470 | 2.75E-03 | 5.13E-03 | 2.82E-02 | 1.55E-02 | Yes |
| TMEM116 | 12 | rs653178 | 1.00E-03 | 1.98E-02 | 2.60E-02 | 1.13E-02 | Yes |
| CDC16 | 13 | rs11617448 | 1.58E-02 | 1.72E-04 | 7.73E-04 | 2.36E-04 | NR |
| EXOSC6 | 16 | rs3790085 | 7.17E-03 | 1.18E-02 | 1.39E-02 | 1.20E-02 | NR |
| CRLF3 | 17 | rs3760318 | 4.25E-03 | 9.56E-03 | 2.00E-02 | 1.20E-02 | NR |
| ZNF100 | 19 | rs2968084 | 1.85E-04 | 2.89E-04 | 9.57E-05 | 1.74E-04 | NR |
a
NR: No Reported.