REAGENT or RESOURCE	SOURCE	Cat#
Antibodies
Anti-mouse CD47 antibody, PeCy7	Biolegend	127524; RRID:AB_2629545
Anti-mouse CD19 antibody PE PeCy7	BD Biosciences BD Biosciences	557399; RRID:AB_396682 552854; RRID:AB_394495
Anti-mouse CD31 antibody, PE	Biolegend	102407; RRID:AB_312902
Anti-mouse CD11b antibody PE PerCP-Cy5.5 APC	BD Biosciences BD Biosciences ThermoFisher Scientific	557397; RRID:AB_396680 550993; RRID:AB_394002 17-0112-82; RRID:AB_469343
CD16/CD32 monoclonal antibody, PE	eBioscience	12-0161-82; RRID:AB_465568
Anti-mouse CD45 antibody, PE	BD Biosciences	553081; RRID:AB_394611
F4/80 monoclonal antibody APC Pacific Blue PE	ThermoFisher Scientific	17-4801-82; RRID:AB_2784648 MF48028; RRID:AB_10373419 12-4801-82; RRID:AB_465923
Anti-mouse CD4 antibody PerCP PE	BD Biosciences BD Biosciences	561090; RRID:AB_10562560 553653; RRID:AB_394973
Anti-mouse CD93 antibody, APC	Biolegend	136509; RRID:AB_2275879
Anti-mouse CD11c antibody APC V450	BD Biosciences BD Biosciences	550261; RRID:AB_398460 560521; RRID:AB_1727423
TruStain fcX™ (anti-mouse CD16/32) antibody	Biolegend	101320; RRID:AB_1574975
Anti-mouse CD172a (SIRPa) antibody APC BV421	Biolegend BD Bioscineces	144014; RRID:AB_2564061 740071; RRID:AB_2739835
Anti-mouse CD8 antibody, Pacific Blue	BD Biosciences	558106; RRID:AB_397029
Anti-mouse Ly6G antibody APC FITC	Biolegend BD Biosciences	127614; RRID:AB_2227348 561105; RRID:AB_10562567
Granzyme B monoclonal antibody, APC	ThermoFisher Scientific	MHGB05; RRID:AB_10373420
Anti-mouse CD107a antibody, PE	BD Biosciences	558661; RRID:AB_1645247
iNOS monoclonal antibody, PeCy7	ThermoFisher Scientific	25-5920-82; RRID:AB_2573499
Human/mouse Arginase 1 antibody, APC	Bio-Techne	IC5868A; RRID:AB_2810265
Anti-mouse CD80 antibody, V450	BD Biosciences	560523; RRID:AB_1727515
Anti-mouse CD86 antibody, PeCy7	BD Biosciences	560582; RRID:AB_1727518
Anti-mouse I-A/I-E antibody, BV510	Biolegend	107636; RRID:AB_2734168
Anti-rabbit IgG DyLight 649	Biolegend	406406; RRID:AB_1575135
Anti-hemoglobin alpha (HBA) antibody	Novus Biologicals	NBP2-67716; RRID:AB_2809609
Anti-hemoglobin beta (HBB) antibody	Invitrogen	PA-576877; RRID:AB_2720604
Anti-SARS-CoV-2-NP	Bioss	ABIN6952435; RRID:AB_2890255
Peroxidase-AffiniPure Goat Anti-Mouse IgG (H+L)	Dianova	115-035-003; RRID:AB_10015289
Anti-mouse MAC-3	Biolegend	108502; RRID:AB_313383
HRP-Goat Anti-Rat IgG (H+L)	ThermoFisher Scientific	A18865; RRID:AB_2535642
Bacterial and virus strains
Influenza A/PR/8/34	Prof. Dr. P. Stäheli (Department of Virology, University Freiburg)	N/A
SARS-CoV-2 B.1.1.10	Patient material (Heilingloh et al.)	N/A
Chemicals, peptides, and recombinant proteins
2N H2SO4	Roth	X873
Avicel	Sigma Aldrich	11365
Bovine Serum Albumin (BSA)	Biomol	01400.100
Brefeldin A	Sigma Aldrich	B 7651
Clodronate Liposomes & Control Liposomes (PBS)	Liposoma B.V.	N/A
Collagenase D	Roche Life Science	11088866001
Corning® Dispase	Corning	354235
Crystal violet	Roth	T 123.1
Diaminobenzidine (DAB)	Dako Agilent	K3467
Dispase	Corning	354235
DNase I	Roche Life Science	10104159001
DNase I from bovine prancreas	Merck KGaA	D4263
Ethylenediaminetetraacetic acid (EDTA)	Roth	8043.2
Fixable viability dye, eFluor 780	ThermoFisher Scientific	65-0865-18
Gentamycin	Sigma Aldrich	G 1272
Goat Serum	Invitrogen	31872
GoTaq® DNA Polymerase	Promega	M3001
Igepal	Sigma Aldrich	I8896
Ionomycin	Sigma Aldrich	I 0634
L-Glutamine	Sigma Aldrich	G 7513
LE Agarose	Biozym	840004
M-MLV Reverse Transcriptase	Promega	M 3683
Matrigel (Basement Membrane Matrix) Matrigel	Corning	354230
Murine Hemoglobin protein	Fitzgerald Industries	FGI-30-1135
Paraformaldehyde (PFA)	Roth	0335.2
pHrodo Green E. coli BioParticles	ThermoFisher Scientific	P35366
Recombinant Mouse Thrombospondin-1 (TSP-1)	R&D Systems	7859-TH-050
RNase-Free DNase Set	Qiagen	79254
ROTI Histofix	Roth	P087.3
TMB Substrate Solution	Biolegend	421101
Triton X-100	Roth	3051.4
Trypsin/EDTA	Sigma Aldrich	T4174
Trypsin from bovine prancreas	Sigma Aldrich	T8802
Tween 20	Roth	9127
Critical commercial assays
AlexaFluor 647 Protein Labeling Kit	ThermoFisher Scientific	A20173
FoxP3 Staining Buffer Set	eBioscience	00-5523-00
Luminex Assay	Bio-Techne	N/A
LumiKine Xpress mIFN-α/-β 2.0 ELISA Kit	Invivogene	Luex-mifnav2 / Luex-mifnbv2
Maxima SYBR Green qPCR Kit	ThermoFisher Scientific	K0222
MouseFree Hemoglobin ELISA Kit	Novus Biologicals	NBP2-59999
Nucleo Spin RNA XS	Macherey-Nagel	740902.250
RNeasy Mini Kit	Qiagen	74106
Deposited data
MicroArray data	This paper	GEO: GSE201825
Experimental models: Cell lines
A549-AT	Dr. Marek Widera (Institute of Virology, University Frankfurt)	N/A
Madin-Darby canine kidney (MDCK)	Prof. Dr. P. Stäheli (Department of Virology, University Freiburg)	N/A
Experimental models: Organisms/strains
CD47−/− mice	Jackson Laboratory	003173
C57BL/6 wildtype mice	Envigo	057
SIRPα−/− mice	Riken Bioresource Center	RBRC01544
Oligonucleotides
Forward primer for matrix gene M1 5′- CTTCTAACCGAGGTCGAAACG-3′	Eurofins	N/A
Reverse primer for matrix gene M1 5′-AGGGCATTTTGGACAAAGTCGTCTA-3′	Eurofins	N/A
Forward primer for Rps9 5′-CTGGACGAGGGCAAGATGAAGC-3′	Eurofins	N/A
Reverse primer for Rps9 5‘-TGACGTTGGCGGATGAGCACA-3‘	Eurofins	N/A
Forward primer for canis Ifnb 5‘-CAGTTCCAGAAGGAGGACA-3’	Eurofins	N/A
Reverse primer for canis Ifnb 5′-TGTCCCAGGTGAAGTTTTCC-3′	Eurofins	N/A
Forward primer for canis Mx1 5′- GAATCCTGTACCCAATCATGTG-3′	Eurofins	N/A
Reverse primer for canis Mx1 5′-TACCTTCTCCTCATATTGGCT-3′	Eurofins	N/A
Forward primer for canis Rps9 5′-GGCCAAGTCCATCCACCAT-3′	Eurofins	N/A
Reverse primer for canis Rps9 5′-GGCGGCCACCCCCATAC-3′	Eurofins	N/A
Software and algorithms
BD FACSDivaTM software v 8.0.1	BD Biosciences	N/A
Fiji	Schindelin et al., 201246	N/A
Prism 7	GraphPad Software	N/A
Other
Dulbecco’s Modified Eagle Medium	Invitrogen	41966029
Opti-MEM	Invitrogen	31985047
Fetal Bovine Serum	Sigma Aldrich	F7524-500ML
Rosswell Memorial Park Institute Medium	Invitrogen	72400-021