Table-4.

Associations of clinicopathological features with COX-2 expression in HGAs.

Clinicopathologic features	Number of samples	COX-2 expression				p-value
		Negative (%)	Weak (%)	Moderate (%)	Strong (%)
Age, years						0.613
<10	14	3 (21.4)	11 (78.6)	0 (0.0)	0 (0.0)
>10	6	2 (33.3)	4 (66.7)	0 (0.0)	0 (0.0)
Sex						1.000
Intact females	1	0 (0.0)	1 (100.0)	0 (0.0)	0 (0.0)
Spayed females	2	0 (0.0)	2 (100.0)	0 (0.0)	0 (0.0)
Castrated males	0	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Intact males	17	5 (29.4)	12 (70.6)	0 (0.0)	0 (0.0)
Tumor size, cm						1.000
<3	12	3 (25.0)	9 (75.0)	0 (0.0)	0 (0.0)
3–5	8	2 (25.0)	6 (75.0)	0 (0.0)	0 (0.0)
>5	0	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Location						0.053
Perianal	17	3 (17.6)	14 (82.4)	0 (0.0)	0 (0.0)
Tail based	2	2 (100.0)	0 (0.0)	0 (0.0)	0 (0.0)
Prepuce	1	0 (0.0)	1 (100.0)	0 (0.0)	0 (0.0)
Perivulva	0	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Ulceration						0.560
Present	5	2 (40.0)	3 (60.0)	0 (0.0)	0 (0.0)
Absent	15	3 (20.0)	12 (80.0)	0 (0.0)	0 (0.0)
Necrosis						1.000
Present	2	0 (0.0)	2 (100.0)	0 (0.0)	0 (0.0)
Absent	18	5 (27.8)	13 (72.2)	0 (0.0)	0 (0.0)
Tissue invasion						N/A
Present	0	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Absent	20	5 (25.0)	15 (75.0)	0 (0.0)	0 (0.0)
Lymphatic metastasis						0.140
Present	0	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Absent	17	3 (17.6)	14 (82.4)	0 (0.0)	0 (0.0)
N/A	3	2 (66.7)	1 (33.3)	0 (0.0)	0 (0.0)

HGAs=Hepatoid gland adenomas, COX-2=Cyclooxygenase-2