Figure 2: Quantification of staining intensity for brush border and adherens junction proteins following 24 h lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-α), and hypoxia treatments.
(A) Villin (red) levels compared among treatments; a = p < 0.0001 compared to control; b = p < 0.05 compared to control; c = p < 0.0001 compared to hypoxia; d = p < 0.05 compared to hypoxia; e = p < 0.001 compared to TNF-α; f = p < 0.01 compared to LPS + hypoxia; g = p < 0.0001 compared to LPS; and (B) E-cadherin (green) levels compared among treatments; a = p < 0.0001 compared to control; b = p < 0.0001 compared to hypoxia; c = p < 0.01 compared to LPS; d = p < 0.01 compared to TNF-α; e = p < 0.05 compared to LPS + hypoxia. Significance was assessed using one-way analysis of variance (ANOVA) with Tukey's test for post-hoc analysis, presented as mean ± standard error of the mean (SEM) (n ≥ 7/group). Control represents normoxia with PBS as vehicle control.
