Table 2.
Clusters and subnetwork of PPI with a high combined score among the ferroptosis-related DEGs
| Rank | Gene | MCC | DMNC | MNC | Degree | EPC | BottleNeck | EcCentricity | Closeness | Radiality | Betweenness | Stress | ClusteringCoefficient |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Top 10 in network 1 ranked by MCC method | |||||||||||||
| 1 | CP | 6480 | 9 | 9 | 9 | 5.172 | 2 | 1 | 9 | 2.33333 | 1.83333 | 10 | 0.86111 |
| 2 | SLC11A2 | 6480 | 9 | 9 | 9 | 5.164 | 1 | 1 | 9 | 2.33333 | 1.83333 | 10 | 0.86111 |
| 3 | SLC40A1 | 6480 | 9 | 9 | 9 | 5.274 | 1 | 1 | 9 | 2.33333 | 1.83333 | 10 | 0.86111 |
| 4 | TFRC | 6480 | 9 | 9 | 9 | 5.172 | 2 | 1 | 9 | 2.33333 | 1.83333 | 10 | 0.86111 |
| 5 | FTH1 | 5760 | 8 | 8 | 8 | 4.95 | 1 | 0.5 | 8.5 | 2.22222 | 0.66667 | 4 | 0.92857 |
| 6 | FTL | 5760 | 8 | 8 | 8 | 4.948 | 1 | 0.5 | 8.5 | 2.22222 | 0.66667 | 4 | 0.92857 |
| 7 | STEAP3 | 5760 | 8 | 8 | 8 | 5.03 | 1 | 0.5 | 8.5 | 2.22222 | 0.66667 | 4 | 0.92857 |
| 8 | SLC39A14 | 5760 | 8 | 8 | 8 | 5.018 | 1 | 0.5 | 8.5 | 2.22222 | 0.66667 | 4 | 0.92857 |
| 9 | SLC39A8 | 720 | 6 | 6 | 6 | 4.579 | 1 | 0.5 | 7.5 | 2 | 0 | 0 | 1 |
| 10 | HMOX1 | 720 | 6 | 6 | 6 | 4.335 | 1 | 0.5 | 7.5 | 2 | 0 | 0 | 1 |
| Top 3 in network 2 ranked by MCC method | |||||||||||||
| 1 | MAP1LC3B | 24 | 0.56839 | 4 | 4 | 3.357 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| 2 | MAP1LC3A | 24 | 0.56839 | 4 | 4 | 3.348 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| 3 | MAP1LC3C | 24 | 0.56839 | 4 | 4 | 3.324 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| Top 5 in network 3 ranked by MCC method | |||||||||||||
| 1 | ACSL1 | 24 | 0.56839 | 4 | 4 | 2.038 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| 2 | ACSL3 | 24 | 0.56839 | 4 | 4 | 2.014 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| 3 | ACSL5 | 24 | 0.56839 | 4 | 4 | 2.016 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| 4 | ACSL4 | 24 | 0.56839 | 4 | 4 | 2.042 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |
| 5 | ACSL6 | 24 | 0.56839 | 4 | 4 | 2.03 | 1 | 1 | 4 | 1.5 | 0 | 0 | 1 |