Table 4.
Cox proportional hazard regression model analysis of disease-free survival in 91 patients with retroperitoneal liposarcoma
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% confidence interval | P value | Hazard Ratio | 95% confidence interval | P value | |
| Siglec-15 | ||||||
| Low-expression | 1 | 1 | ||||
| High-expression | 2.120 | 1.105-4.068 | 0.024 | 2.298 | 1.154-4.576 | 0.018 |
| PD-L1 | ||||||
| Low-expression | 1 | |||||
| High-expression | 1.808 | 0.710-4.606 | 0.215 | |||
| Gender | ||||||
| Male | 1 | |||||
| Female | 0.911 | 0.498-1.666 | 0.763 | |||
| Age | ||||||
| ≤60 | 1 | |||||
| >60 | 0.619 | 1.118-2.020 | 0.711 | |||
| Tumor size | 0.019 | 0.049 | ||||
| ≤15 | 1 | 1 | ||||
| 15-30 | 0.500 | 0.236-1.061 | 0.071 | 1.160 | 0.685-1.963 | 0.580 |
| >30 | 1.303 | 0.597-2.842 | 0.506 | 0.605 | 0.398-0.919 | 0.018 |
| FNCLCC grade | ||||||
| Low (G1) | 1 | 1 | ||||
| High (G2, G3) | 1.812 | 0.840-3.910 | 0.130 | 1.598 | 0.655-3.902 | 0.303 |
| Histology | 0.092 | 0.088 | ||||
| DDLPS | 1 | 1 | ||||
| WDLPS | 0.303 | 0.118-0.776 | 0.013 | 0.301 | 0.110-0.820 | 0.019 |
| PLPS | 0.913 | 0.353-2.359 | 0.866 | 1.453 | 0.534-3.957 | 0.465 |
| MLPS | <0.001 | * | 0.978 | <0.001 | * | 0.980 |
| Multifocality | ||||||
| No | 1 | |||||
| Yes | 1.442 | 0.802-2.593 | 0.221 | |||
| Recurrence | ||||||
| No | 1 | 1 | ||||
| Yes | 1.883 | 1.031-3.438 | 0.039 | 1.315 | 0.684-2.530 | 0.412 |
| Necrosis | ||||||
| No | 1 | 1 | ||||
| Yes | 1.744 | 0.960-3.169 | 0.068 | 2.052 | 1.082-3.890 | 0.028 |
Abbreviations: Siglec-15, sialic acid-binding immunoglobulin-like lectin-15; PD-L1, programmed death ligand 1; NCLCC, Federation Nationale des Centres de Lutte Contre le Cancer; WDLPS, well-differentiated liposarcoma; DDLPS, dedifferentiated liposarcoma; PLPS, pleomorphic liposarcoma; MLPS, myxoid/round cell liposarcoma.
* means the sample size included is too small to be estimated.
The bold P value indicated significant difference.