Table 5.
Cox proportional hazard regression model analysis of overall survival in 91 patients with retroperitoneal liposarcoma
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Hazard Ratio | 95% confidence interval | P value | Hazard Ratio | 95% confidence interval | P value | |
| Siglec-15 | ||||||
| Low-expression | 1 | |||||
| High-expression | 1.108 | 0.615-1.996 | 0.734 | |||
| PD-L1 | ||||||
| Low-expression | 1 | |||||
| High-expression | 1.374 | 0.491-3.847 | 0.546 | |||
| Gender | ||||||
| Male | 1 | |||||
| Female | 1.392 | 0.783-2.472 | 0.260 | |||
| Age | ||||||
| ≤60 | 1 | |||||
| >60 | 1.215 | 0.678-2.178 | 0.513 | |||
| Tumor size | 0.027 | 0.021 | ||||
| ≤15 | 1 | 1 | ||||
| 15-30 | 0.695 | 0.391-1.233 | 0.213 | 0.680 | 0.365-1.267 | 0.225 |
| >30 | 0.815 | 0.538-1.236 | 0.336 | 0.799 | 0.522-1.224 | 0.302 |
| FNCLCC grade | ||||||
| Low (G1) | 1 | 1 | ||||
| High (G2, G3) | 2.473 | 1.040-5.881 | 0.041 | 1.681 | 0.658-4.294 | 0.278 |
| Histology | 0.165 | 0.154 | ||||
| DDLPS | 1 | 1 | ||||
| WDLPS | 0.377 | 0.158-0.897 | 0.027 | 0.355 | 0.145-0.872 | 0.024 |
| PLPS | 0.849 | 0.302-2.393 | 0.757 | 0.865 | 0.305-2.455 | 0.785 |
| MLPS | 1.439 | 0.195-10.606 | 0.721 | 1.324 | 0.177-9.913 | 0.785 |
| Multifocality | ||||||
| No | 1 | |||||
| Yes | 1.139 | 0.639-2.033 | 0.658 | |||
| Recurrence | ||||||
| No | 1 | |||||
| Yes | 1.247 | 0.698-1.225 | 0.456 | |||
| Necrosis | ||||||
| No | 1 | 1 | ||||
| Yes | 1.835 | 1.028-3.274 | 0.040 | 1.806 | 1.002-3.254 | 0.049 |
Abbreviations: Siglec-15, sialic acid-binding immunoglobulin-like lectin-15; PD-L1, programmed death ligand 1; NCLCC, Federation Nationale des Centres de Lutte Contre le Cancer; WDLPS, well-differentiated liposarcoma; DDLPS, dedifferentiated liposarcoma; PLPS, pleomorphic liposarcoma; MLPS, myxoid/round cell liposarcoma.
The bold P value indicated significant difference.