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MS/MS spectra of tazobactam-modified peptides. A representative MS/MS spectrum shows a HSA peptide K*QTALVELVK that was modified by tazobactam with a mass addition of 88 Da (A). A similar adduct was also detected when clavulanate was incubated with HSA (B). Albumin peptides modified by clavulanate or tazobactam were identified in vitro. Clavulanate and tazobactam were incubated with HSA for 24 h at a drug protein molar ratio of 20:1 and 200:1, respectively.
