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. 2022 Oct 18;18(16):6129–6144. doi: 10.7150/ijbs.74951

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Over-expressed BMAL1 attenuated HCC cell proliferation and metastasis. (A and B) MTS and colony formation assays for determining the growth potential of MHCC97H and Hep-3B cells after treatment as indicated (BMAL1, expression vector encoding BMAL1; EV, empty vector). (C and D) Scratch-wound-healing and Matrigel invasion assays for assessment of metastatic abilities of MHCC97H and Hep-3B cells after treatments as indicated. (E) Subcutaneous tumor-growth curves for HCC cells stably transfected with the expression vector encoding BMAL1 (n=6 mice/group). (F) Dissected subcutaneous tumors (left panel) and their weights (right panel) (n=6 mice/group). (G) The number of lung metastasis nodules in each group (n=6 mice/group). Scale bar, 100 µm. *p <0.05.