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. 2022 Oct 18;18(16):6129–6144. doi: 10.7150/ijbs.74951

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BMAL1 suppressed HCC cell growth and metastasis by inhibiting GPAM. (A and B) MTS and colony formation assays for treated SNU-368 and MHCC97H cells. (C and D) Scratch-wound-healing and matrigel invasion assays for migration and invasive potentials of specifically treated SNU-368 and SNU-739 cells. (E) Subcutaneous tumor-growth curves for HCC cells stably transfected with the expression vector encoding BMAL1 (n=6 mice/group). (F) Dissected subcutaneous tumors f (left panel), with their weights (right panel) (n=6 mice/group). (G) Number of lung metastasis nodules in each group (n=6 mice/group). Scale bar, 100 µm. *p <0.05.