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. 2022 Oct 24;18(16):6163–6175. doi: 10.7150/ijbs.78354

Figure 5.

Figure 5

ADCK2 depletion disrupts mitochondrial functions in NSCLC cells. “ADCK2-sh”, “ADCK2-ko” or “shScr+koC” pCan-1 cells were cultured, mitochondrial depolarization (by recording intensity of JC-1 green monomers, A), cytosol cytochrome C protein levels (B), lipid peroxidation (TBAR intensity, C), as well as ssDNA contents (D), expression of DNA-damage related-proteins (E), mitochondrial complex I activity (F) and ATP contents (G) were tested. “pCan2” and “pCan3” primary cells or the established A549 cells, with “ADCK2-sh” or “shScr”, were cultured, mitochondrial depolarization (H), the ssDNA contents (I), mitochondrial complex I activity (J) and ATP contents (K) were tested similarly. * P < 0.05 vs. “Pare” or “shSCR”. Scale bar = 100 µm.