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. 2022 Oct 18;18(16):6114–6128. doi: 10.7150/ijbs.74924

Figure 2.

Figure 2

The accumulation of LDs is involved in the regulation of fibroblast activation. (A) The lipid-tox red staining of fibroblasts (NIH 3T3 and MEF) that were treated with/without sodium oleate (50 µM) and the LDs inhibitors (iDGAT: iDGAT1-10 µM+ iDGAT2-10 µM, iSCD1-100 nM, iMAGL-20 nM; Scale bar: 100 µm) for 12h (N = 5). (B) The BODIPY staining (FITC) of fibroblasts (NIH 3T3 and MEF) that were treated with/without sodium oleate (50 µM) and the LDs inhibitors (iDGAT, iSCD1 and iMAGL) for 12h (N = 3). (C) The protein expression of α-SMA and COLlA2 in fibroblasts (NIH 3T3 and MEF) that were treated with/without sodium oleate (50 µM) and the LDs inhibitors (iDGAT, iSCD1 and iMAGL) for 24h (N = 3). Data are shown as the Mean±SD; *p < 0.05, ** p< 0.01, ***p < 0.001.