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. 2022 Oct 18;18(16):6114–6128. doi: 10.7150/ijbs.74924

Figure 5.

Figure 5

SCD1-overexpressing fibroblasts promote lung cancer growth. (A and B) The BODIPY staining and CD36 expression of tumor cells (LLC cells) after co-cultured with or without NIH 3T3-SCD1-MOCK cells and NIH 3T3-SCD1-OVER cells (N = 5). (C) The distribution and LD contents of tumor cells (LLC-GFP cells) that were co-cultured with SCD1-MOCK and SCD1-OVER fibroblasts (NIH 3T3) by lipid-tox red staining (Scale bar: 50 µm, N = 3). (D) The LLC cells with or without NIH 3T3-SCD1-MOCK cells or NIH 3T3-SCD1-OVER cells were subcutaneously co-injected into the C57 mice (N = 8 mice/group) and the tumor volumes were measured every two days. (E) The representative tumor images and tumor weights are presented. (F) Representative immunofluorescence images of PCNA (red) in the frozen sections from the tumor tissues (Scale bar: 50 µm). Data are shown as the Mean±SD; NS: p ≥ 0.05, *p < 0.05, **p < 0.01.