Table 1 |.

Summary of the 14 genome-wide significant loci identified in GWAS analyses of opioid use disorder

Chr	Position (GRCh37/hg19) of lead SNPs	Nearest genes	GWAS analysis
5	43846681	NNT	AA (less stringent)
6	21362610, 21478361	CDKAL1, SOX4	Cross-ancestry (less stringent), HA (less stringent), cross-ancestry (meta)
6	32383573	BTNL2	Cross-ancestry (less stringent)
6	154360797, 154380719, 154382139, 154393680, 154396472	OPRM1	Cross-ancestry (less stringent), EA (less stringent), cross-ancestry (stringent), EA (stringent), cross-ancestry (meta), EA (meta)
6	24394925	MRS2	HA (less stringent)
8	143312933, 143316970	TSNARE1	Cross-ancestry (stringent), EA (stringent), EA (meta)
9	127873473, 127959540, 127980426	SCAI, RABEPK	Cross-ancestry (less stringent), cross-ancestry (meta), EA (meta)
10	103414885	FBXW4	Cross-ancestry (less stringent), EA (less stringent), EA (meta)
10	110504365	[]	Cross-ancestry (less stringent)
11	112869404	NCAM1	Cross-ancestry (less stringent)
15	91410009, 91406146, 91426560	FURIN	Cross-ancestry (less stringent), EA (less stringent), cross-ancestry (stringent), EA (stringent), cross-ancestry (meta), EA (meta)
16	61631362	CDH8	EA (less stringent), EA (stringent)
19	18093588	KCNN1	Cross-ancestry (less stringent), AA (less stringent), cross-ancestry (meta), AA (meta)
20	48540277, 48583726	RNF114	Cross-ancestry (less stringent), cross-ancestry (meta)

Chr, chromosome number.