Supplement Table 1C.

Summary of Findings and Strength of Evidence (GRADE) for 1-Year Results

TAVI Compared to SAVR for Low-Risk Surgical Patients with Aortic Stenosis
Patient or population: low-risk surgical patients with aortic stenosis Settings: Intervention: TAVI1 Comparison: SAVR2
Outcomes	Illustrative Comparative Risks* (95% CI)		Relative Effect (95% CI)	No of Participants (Studies)	Quality of the Evidence (GRADE)	Comments
Assumed Risk	Corresponding Risk
	SAVR	TAVI
All-cause mortality Follow-up: 1 year	Study population		RR 0.66 (0.41-1.06)	2633 (3 studies)	⊕⊕⊕⊕ High
	32 per 1000	21 per 1000 (13-34)
	Moderate
30 per 1000	21 per 1000 (12-32)
Cardiovascular mortality Follow-up: 1 year	Study population		RR 0.56 (0.33-0.94)	2633 (3 studies)	⊕⊕⊕⊕ High
	29 per 1000	16 per 1000 (10-27)
	Moderate
27 per 1000	15 per 1000 (9-25)
Stroke Follow-up: 1 year	Study population		RR 0.71 (0.4-1.25)	2633 (3 studies)	⊕⊕⊕⊕ High
	39 per 1000	27 per 1000 (15-48)
	Moderate
43 per 1000	31 per 1000 (17-54)
Transient ischemic attack Follow-up: 1 year	Study population		RR 0.98 (0.52-1.83)	2633 (3 studies)	⊕⊕⊕⊕ High
	15 per 1000	15 per 1000 (8-27)
	Moderate
15 per 1000	15 per 1000 (8-27)
Myocardial infarction Follow-up: 1 year	Study population		RR 0.74 (0.43-1.27)	2633 (3 studies)	⊕⊕⊕⊕ High
	23 per 1000	17 per 1000 (10-29)
	Moderate
22 per 1000	16 per 1000 (9-28)
Life-threatening or disabling bleeding Follow-up: 1 year	Study population		RR 0.32 (0.24-0.42)	2353 (2 studies)	⊕⊕⊕⊕ High
	156 per 1000	50 per 1000 (38-66)
	Moderate
173 per 1000	55 per 1000 (42-73)
Permanent pacemaker implantation Follow-up: 1 year	Study population		RR 3.42 (1.33-8.82)	2633 (3 studies)	⊕⊕⊕⊝ Moderate3,4
	57 per 1000	194 per 1000 (76-501)
	Moderate
53 per 1000	181 per 1000 (70-467)
New-atrial fibrillation Follow-up: 1 year	Study population		RR 0.25 (0.18-0.36)	2633 (3 studies)	⊕⊕⊕⊕ High3,4
	386 per 1000	96 per 1000 (69-139)
	Moderate
384 per 1000	96 per 1000 (69-138)
*The basis for the assumed risk (e.g., the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). RR, risk ratio.
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.
1Transcatheter aortic valve implantation; 2surgical aortic valve replacement; 3inconsistency; 4large effect.