Input parameters and results from DoE response surface methodology performed in flow Pd(OAc)₂/pyridine catalyzed aerobic oxidation of 1.^a.

Entry	Catalyst loading (mol%)	T (°C)	V of reagents (mL min−1)	Conv. of 1b (%)	Yield of 2b (%)	Yield of 3b (%)
1	5	80	0.1	0.4	0.4	0.0
2	5	80	1.0	17.0	17.0	0.0
3	5	120	0.1	12.3	0.0	12.2
4	5	120	1.0	6.4	0.4	6.0
5	40	80	0.1	20.8	0.0	20.8
6	40	80	1.0	41.2	0.0	41.2
7	40	120	0.1	36.3	0.0	36.3
8	40	120	1.0	70.4	0.0	70.4
9	5	100	0.55	6.0	4.4	1.6
10	40	100	0.55	27.4	0.0	27.4
11	22.5	80	0.55	6.5	0.0	6.5
12	22.5	120	0.55	39.1	0.0	39.1
13	22.5	100	0.1	22.3	0.0	22.3
14	22.5	100	1.0	15.0	0.0	15.0
15	22.5	100	0.55	24.1	0.0	24.1
16	22.5	100	0.55	22.6	0.0	22.6
17	22.5	100	0.55	22.6	0.0	22.6

^aStandard reaction conditions: substrate 1 = 20 mg (0.05 mmol) dissolved in 2 mL toluene/caprolactone = 1 : 1; P_O2 = 5 bar; catalyst/pyridine = 1/1.3; V_O2 = 0.1 mL min⁻¹.

^b% determined by UHPLC for details see ESI.