Table 2.

Sedative and Analgesic management

	Dexmedetomidine (n = 51)	Usual care (n = 52)	p
Received dexmedetomidine, n (%)§	49 (96.1)	2 (3.8)	< 0.01
Received midazolam, n (%)	17 (33.3)	30 (57.7)	0.01
Received propofol, n (%)	43 (84.3)	48 (92.3)	0.21
Received fentanyl, n (%)	50 (98)	49 (94.2)	0.32
Received morphine, n (%)	11 (21.6)	18 (34.6)	0.14
Duration of dexmedetomidine infusion (days)	4 [2–7]	–	–
Duration of midazolam infusion (days)	1 [1–4]	3 [2–4]	0.04
Duration of propofol infusion (days)	5 [2–8]	4 [2–8]	0.96
Duration of fentanyl infusion (days)	6 [3–9]	6 [3–9]	0.89
Duration of morphine infusion (days)	1 [1–2]	2.5 [2–7]	0.05
Median dexmedetomidine dose (mcg/kg/day)	9.01 [5.0–14.8]	–	–
Median midazolam dose (mg/kg/day)	0.14 [0.08–0.38]	0.46 [0.20–0.93]	0.01
Median propofol dose (mg/kg/day)	7.26 [4.01–15.1]	9.38 [6.24–14.9]	0.38
Median fentanyl dose (mcg/kg/day)	12.2 [8.29–15.8]	11.1 [7.5–15.2]	0.58
Median morphine dose (mg/kg/day),	0.42 [0.07–0.81]	0.71 [0.15–1.7]	0.31
Sedation Index during first 48 h (RASS)*	2.08 [1.5–3.0]	2.26 [1.52–3.56]	0.45
Sedation Index while ventilated (RASS)*	1.91 [1.36–2.43]	2 [1.35–2.35]	0.4
Duration of ventilation (days)	3.73 [1.89–7.73]	5.07 [2.43–10.4]	0.91

Data given as mean (SD), median [95% CI]* Sedation index is calculated as the sum of negative Richmond Agitation Sedation Scale measurements divided by the total number of assessments

^§In the 2 patients from the usual care group who received the median [95%] duration of infusion was 2.5 days [2–3] and a dose of 8.09 [3.76–12.4] (mcg/kg/day)