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. 2022 Nov 21;22:520. doi: 10.1186/s12903-022-02435-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — DEGs analysis in COVID-19 and periodontitis. A Volcano plot of mRNAs expression level in GSE12484. Threshold of P-value < 0.05 and |log2(FC)|> 2 was set. The red dots represented significantly highly expressed genes, and the blue dots represented significantly lowly expressed genes; B Volcano plot of mRNAs expression level in GSE164805. The evaluation criteria included adjust P-value < 0.05 and |log2(FC)|> 2.0. The red dots represented significantly highly expressed genes, and the blue dots represented significantly lowly expressed genes; C The heatmap showed the expression of top 20 up-regulated mRNAs and down-regulated mRNAs in GSE12484; D The heatmap showed the expression of top 20 up-regulated mRNAs and down-regulated mRNAs in GSE164805; E Then venn diagram showed the overlapping parts of GSE164805 and GSE12484: F The tissue-specific expression of the intersected DEGs