Fig. 7.

ECC-BYF III improve CSE-induced excessive cell senescence by suppressing oxidative stress, strengthening mitophagy. A The fluorescence intensity of ROS after intervention with Luteolin; B The protein expressions of NRF2 and HO-1 after intervention with Luteolin. Full-length gels are presented in Supplementary Fig. 4. C The protein expressions of PINK1, PARK2, MFN2, DRP1 after intervention with Luteolin; Full-length gels are presented in Supplementary Fig. 5. D The protein expressions of p16 and p21 after intervention with Luteolin. Full-length gels are presented in Supplementary Fig. 6. The data are expressed as the mean ± SE, (n = 3). ^**P < 0.01 vs. the normal group, ^*P < 0.05 vs. the normal group; ^##P < 0.01 vs. the model group, ^#P < 0.05 vs. the model group; ^△△P < 0.01 vs. the ECC-BYF III treatment group, ^△P < 0.05 vs. the ECC-BYF III treatment group