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. 2022 Nov 22;24:257. doi: 10.1186/s13075-022-02945-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Private sera showed specific binding to cartilage in vitro. A Private sera reactivity to arthritic DBA1/J joint obtained at D90 after 1st immunization (arthritis score > 12) tissue. The x-axis shows the citrulline sites of sera responded peptides. B IHC results of sera that had private response to 12-cit cyclic COL2 peptide. C IHC results of sera that had private response to 19-cit cyclic COL2 peptide (specific to C1 epitope). The sera did not bind to arthritic joint tissue listed: (a) obtained at D90 after immunization from C1 mutated mouse (historic max arthritis score = 14) and (b) arthritic DBA joint tissues as described previously but blocked with 5 mg/ml CB20 before sera incubation