Table 3:
Association between psoas, paraspinal, and oblique muscle group fat fraction and L3 vBMD (mg/cm3) in 950 women and 973 men in the Multi-Ethnic Study of Atherosclerosis
| Psoas | ||||
|---|---|---|---|---|
|
|
||||
| Men | Women | |||
|
| ||||
| β (SD) | P value | β (SD) | P value | |
|
|
||||
| Unadjusted | −220.0 (26.5) | <0.001 | −188.5 (21.7) | <0.001 |
| Age, race, BMI, smoking, IFG, CCS use, anti-resorptive use adjusted | −154.2 (26.3) | <0.001 | −104.3 (20.3) | <0.001 |
| Age, race, BMI, smoking, IFG, CCS use, anti-resorptive use, intentional exercise adjusted * | −147.3 (26.3) | <0.001 | −104.2 (20.3) | <0.001 |
|
| ||||
| Paraspinal | ||||
|
|
||||
| Men | Women | |||
|
| ||||
| β (SD) | P value | β (SD) | P value | |
|
|
||||
| Unadjusted | −138.0 (19.9) | <0.001 | −168.0 (16.3) | <0.001 |
| Age, race, BMI, smoking, IFG, CCS use, anti-resorptive use adjusted | −53.0 (21.2) | 0.011 | −86.7 (16.6) | <0.001 |
| Age, race, BMI, smoking, IFG, CCS use, anti-resorptive use, intentional exercise adjusted * | −50.3 (21.2) | 0.012 | −86.0 (16.4) | <0.001 |
|
| ||||
| Oblique | ||||
|
|
||||
| Men | Women | |||
|
| ||||
| β (SD) | P value | β (SD) | P value | |
|
|
||||
| Unadjusted | −80.9 (24.6) | 0.001 | −76.8 (16.9) | <0.001 |
| Age, race, BMI, smoking, IFG, CCS use, anti-resorptive use adjusted | −52.2 (22.5) | 0.022 | −47.12 (15.3) | 0.001 |
| Age, race, BMI, smoking, IFG, CCS use, anti-resorptive use, intentional exercise adjusted * | −51.8 (22.5) | 0.034 | −48.2 (15.3) | 0.001 |
SD= standard deviation. BMI = Body mass index (kg/m2). IFG=Impaired fasting glucose. CCS = Corticosteroid. Analysis for fat fraction was in increments of 10%.
*
Following evaluation of intentional exercise as an effect modifier on the association between muscle density, fat fraction, and L3 vBMD, we found no significant interaction. Therefore, we considered it a confounder and adjusted for it in Model 3.