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. Author manuscript; available in PMC: 2022 Nov 23.
Published in final edited form as: Biol Psychiatry. 2020 Jul 12;89(8):786–794. doi: 10.1016/j.biopsych.2020.06.029

Figure 5.

Figure 5.

Amyloid-β (Aβ) (A), tau (T), and neurodegeneration (N) in relation to cognition. Estimates of association with longitudinal preclinical Alzheimer’s cognitive composite changes of Aβ positron emission tomography (PET), 18F-flortaucipir (FTP) standardized uptake value ratio, and adjusted hippocampal volume (aHCV), as well as their interactions in a linear mixed-effects model in 299 participants with longitudinal cognitive data. The error bars indicate 95% confidence interval of the estimated β coefficient. Aβ*FTP, Aβ*aHCV, aHCV*FTP, and Aβ*FTP*aHCV indicate the interaction between Aβ and FTP; Aβ and aHCV; aHCV and FTP; and Aβ, and FTP and aHCV, respectively. *p < .05; **p < .01.