TABLE 1.

RNA sequencing pathway analysis

Differentially expressed genes	Name	P value	Adjusted P value	Genes
Upregulated (575 genes)	Olfactory transduction	0.0003459	0.09513	OR2C1, OR4Q2, OR8U1, OR2S2, OR2AE1, OR2W3, OR10W1, OR2AG2, OR11H6, OR56B1, OR8B4, OR5AP2, OR5B2, OR52B6, OR4D2, OR2B2, OR2T27, OR6J1, OR6N1, OR5P3, OR5P2, OR10A7, OR4K15, OR9A4, OR51T1, OR52A5
	Hormone ligand-binding G-protein coupled receptors	0.003283	0.4514	CGA, FSHR, GNRH2
	Signaling by GPCR	0.006266	0.5355	CXCL6, OR2C1, DHH, OR4Q2, RXFP2, PIK3R6, OR8U1, OR2S2, OR2AE1, OR2W3, OR10W1, NPY, OR2AG2, OR56B1, OR8B4, OR5AP2, CGA, HCRT, DRD3, OR5B2, WNT2, INSL5, OR52B6, DRD5, NTSR2, CCR2, OR4D2, OR2B2, OR2T27, WNT10A, OR6J1, TAAR5, OR6N1, OR5P3, OR5P2, OR10A7, OR4K15, OR9A4, FSHR, OR51T1, GNRH2, OR52A5
	Dopamine receptors	0.007789	0.5355	DRD5, DRD3
	Relaxin receptors	0.02059	1	RXFP2, INSL5
	Defensins	0.03982	1	DEFB121, DEFB124, DEFA6
Downregulated (65 genes)	HIF-1 transcriptional activity in hypoxia	2.377E-06	0.0004137	BHLHE40, SLC2A1, ADM, CA9, HK2
	BDNF signaling pathway	2.171E-05	0.001889	FOXC1, P4HA1, GDF15, IGFBP3, ADM, HSPA1B, HSPA1A
	Apoptosis modulation by HSP70	0.001716	0.05855	HSPA1B, HSPA1A
	Glycolysis and gluconeogenesis	0.001872	0.05855	SLC2A1, PCK1, HK2
	Transcriptional regulation of white adipocyte differentiation	0.002019	0.05855	CEBPB, ANGPTL4, PCK1
	p53 signaling pathway	0.001089	0.05855	BNIP3L, GDF15, IGFBP3, HSPA1B