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. 2022 Nov 9;13:944837. doi: 10.3389/fgene.2022.944837

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Copyright © 2022 Brandenburg, Griswold, Van Booven, Kilander, Frei, Nestor, Dykxhoorn, Pericak-Vance and Blatt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heat map of differentially expressed genes. Of the total 427 differently expressed genes, 360 were down-regulated and 67 were up-regulated in ASD cases. Both the genes (rows) and cases (columns) were clustered using dendrograms constructed using Euclidean distances and hierarchical clustering and grouped by case demographics. (B) STRINGdb analysis of the differentially expressed genes that were decreased in the cases compared to the controls. The network was divided into clusters using the MCL inflation parameter and the top 4 clusters were analyzed for enrichment of Gene Ontology processes and the top 10 processes for each cluster are represented.