Figure 1.

Targeted rectal mucosal gene expression of treatment-naïve paediatric UC patients at diagnosis compared to non-IBD patients. [A] Dendrogram and heatmap of unsupervised hierarchical clustering based on normalized expression of 23 genes as assessed by microfluidic RT-qPCR gene expression array. All p-values are false discovery rate-corrected. NS, not significant; *p < 0.05; **p < 0.01; ***p < 0.001 vs non-IBD controls. [B] Violin plots showing analytes significantly associated with endoscopic Mayo score. The y-axis units are log₂ gene expression relative to controls. *p < 0.05; **p < 0.01; ***p < 0.001 for Spearman’s correlation coefficient across endoscopic Mayo scores 1–3 .