Figure 2.

Change in targeted rectal mucosal gene expression from paediatric UC patients between diagnosis and week 52. [A] Dendrogram and heatmap denoting significantly altered gene expression between week 0 and week 52 as assessed by microfluidic RT-qPCR gene expression array for study patients [n = 58] with endoscopic healing [EH, endoscopic Mayo score 0] compared to not healed [no EH, endoscopic Mayo score 1–3]. [B] Spaghetti plots with overlying growth curves showing differential change in gene expression from week 0 to week 52 between those with and without endoscopic healing at week 52. The y-axis units are log₂ gene expression relative to non-IBD control patients.