Comparison 3. Subgroup analysis: death or non‐recovery of kidney function at day 90.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 AKI aetiology	6	4011	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.74, 1.11]
3.1.1 Non‐surgical causes	3	3646	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.97, 1.11]
3.1.2 Surgical causes	3	365	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.33, 1.33]
3.2 AKI criteria	6	4011	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.74, 1.11]
3.2.1 KDIGO stage 2	1	619	Risk Ratio (M‐H, Random, 95% CI)	0.95 [0.79, 1.15]
3.2.2 KDIGO stage 3/RIFLE‐F AKIN	3	3258	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.70, 1.19]
3.2.3 Other criteria	2	134	Risk Ratio (M‐H, Random, 95% CI)	0.47 [0.07, 3.21]
3.3 KRT modality	6	4011	Risk Ratio (M‐H, Random, 95% CI)	0.91 [0.74, 1.11]
3.3.1 Continuous KRT	3	365	Risk Ratio (M‐H, Random, 95% CI)	0.66 [0.33, 1.33]
3.3.2 Continuous and intermittent KRT	3	3646	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.97, 1.11]
3.4 Illness severity score	5	3983	Risk Ratio (M‐H, Random, 95% CI)	0.96 [0.83, 1.10]
3.4.1 Sequential Organ Failure Assessment (SOFA) score > 12	2	331	Risk Ratio (M‐H, Random, 95% CI)	0.77 [0.62, 0.97]
3.4.2 Sequential Organ Failure Assessment (SOFA) score ≤ 12	3	3652	Risk Ratio (M‐H, Random, 95% CI)	1.04 [0.97, 1.12]