Skip to main content
. 2022 Nov 23;2022(11):CD010612. doi: 10.1002/14651858.CD010612.pub3

Xia 2019.

Study characteristics
Methods

  • Study design: prospective, open‐label RCT

  • Duration of study: January 2013 to June 2017

  • Duration of follow‐up: until day 28 after randomisation
Participants

  • Setting: single‐centre

  • Country: China

  • Critically ill patients with AKI and sepsis; ≥ 18 years

  • Number: intervention group (30); control group (30)

  • Mean age ± SD (years): intervention group (65.4 ± 12.3); control group (67.49 ± 10.8)

  • Sex (M/F): intervention group (15/15); control group (18/12)

  • Exclusion criteria: patients with malignant tumour; CKD; blood disease, thyroid disease, and long‐term immunosuppression; drugs or glucocorticoids; contraindications to CKRT treatment; breastfeeding or pregnant
Interventions KRT modality

  • CKRT


Intervention group

  • Early‐strategy group: AKI and urinary NGAL level > 1310 ng/mL; CKRT was started within 12 hours after randomisation


Control group

  • Standard‐strategy group: AKI and NGAL < 1310 ng/mL; CKRT intervention started when the patients fulfilled the following criteria

    • Severe metabolic acidosis (pH < 7.20, blood HCO3 < 12 mmol/L)

    • Hyperkalaemia > 6.5 mmol/L

    • Water intoxication (with manifestations of heart failure or pulmonary oedema)
Outcomes Primary outcome

  • Death at day 28


Secondary outcomes

  • Recovery of kidney function

  • Mechanical ventilation time

  • ICU stay

  • Hospital stay

  • Dialysis dependence
Notes

  • This study was supported by the Science and Technology Project, funded by Health Bureau of Shanxi Providence
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Insufficient information to permit judgement
Quote: "All patients were divided randomly into two groups"
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias)
All outcomes Unclear risk Insufficient information to permit judgement (for kidney recovery was unclear risk but for death was low risk)
Blinding of outcome assessment (detection bias)
All outcomes Low risk The outcome measurement is not likely to be influenced by lack of blinding
Incomplete outcome data (attrition bias)
All outcomes Low risk Complete outcome data were reported
Selective reporting (reporting bias) Low risk The study reported death, kidney function recovery, dialysis dependence, ICU and hospital stay.
Other bias Low risk Not for profit funding