Table 3.
Confirmed and putative bacterial virulence factors differentially expressed in glycogen compared with that in glucose.
| Protein | Description | Virulence a | Fold change | p-value |
|---|---|---|---|---|
| Sly | Suilysin | Hemolysin | 41.61 | 0 |
| Ssa | Fibronectin-binding protein | Adhesion ECM | 21.22 | 0 |
| HP0197 | Hypothetical protein | Adhesion ECM | 6.35 | 2.18E-89 |
| PdhA | Pyruvate dehydrogenase, alpha subunit | Adhesion ECM | 4.15 | 6.54E-76 |
| LDH | Lactate dehydrogenase | Adhesion ECM | -2.44 | 2.80E-50 |
| HtpsC | Type II histidine triad protein | Adhesion ECM | -4.55 | 3.16E-84 |
| PGM | Phosphoglycerate mutase | Adhesion ECM | -3.03 | 1.95E-75 |
| AbpB | Amylase-binding protein B | Adhesion epithelium | 120.40 | 0 |
| DnaK | DnaK operon | Adhesion epithelium | 7.09 | 2.56E-92 |
| DnaJ | DnaK operon | Adhesion epithelium | 7.58 | 5.18E-75 |
| SsnA | Surface-anchored DNA nuclease | Adhesion epithelium | 4.15 | 1.49E-115 |
| SadP | Hypothetical protein | Adhesion epithelium | 2.05 | 4.96E-33 |
| ApuA | Amylopullulanase | Adhesion epithelium | 65.44 | 0 |
| GtfA | Glycosidase | Adhesion epithelium | 85.19 | 3.91E-133 |
| MRP | Muramidase released protein | Adhesion epithelium | -9.09 | 3.11E-263 |
| DivIVA | Cell division initiation protein | Adhesion epithelium | -2.08 | 6.49E-35 |
| GlnA | Glutamine synthetase | Adhesion epithelium | -12.5 | 0 |
| Eno | Enolase | Adhesion epithelium | -3.33 | 9.28E-76 |
| SrtA | Sortase A | Adhesion epithelium | -2.13 | 1.59E-29 |
| GlnA | Glutamine synthetase | Adhesion epithelium | -12.5 | 0 |
| PepD | Amynoacyl histidine peptidase | Subtilisin protease | 120.40 | 0 |
| ArcA | Arginine deaminase | Biological fitness | 45.57 | 0 |
| ArcB | Ornithine carbamoyltransferase | Biological fitness | 68.03 | 0 |
| ArcC | Carbamate kinase | Biological fitness | 378.49 | 0 |
| ArgR | Arginine repressor | Biological fitness | 3.21 | 3.69E-10 |
| HepI/III | Oligohyaluronate lyase | Hyaluronidase | 24.34 | 2.00E-212 |
| STP | Serine/threonine protein phosphatase | Regulatory factor | 2.12 | 4.72E-35 |
| STK | Serine/threonine protein kinase | Regulatory factor | 2.13 | 4.54E-37 |
| CcpA | Catabolite control protein A | Regulatory factor | 3.60 | 8.26E-69 |
| GidA | Glucose-inhibited division protein | Regulatory factor | -5.26 | 1.54E-130 |
| RelA | GTP pyrophosphokinase | Regulatory factor | -3.33 | 2.19E-59 |
| DltA | D-alanine-poly ligase | LTA D-alanylation | -2.70 | 4.62E-53 |
a ECM, extracellular matrix; LTA, lipoteichoic acid.